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癌癥疫苗研發(fā)的新選擇 已有1人參與
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poly-ICLC在臨床上多用于肽疫苗,DC疫苗和全細胞疫苗,主要用于多種癌癥疫苗的開發(fā),多個項目已進入2期臨床。在癌癥疫苗中添加poly-ICLC可增強疫苗誘導(dǎo)的抗腫瘤T細胞和NK細胞反應(yīng),從而有助于腫瘤消退或根除。 然而,poly-ICLC 除了具有觸發(fā)強大免疫反應(yīng)的功能外,還可能具有劑量依賴性全身發(fā)熱和凝血異常等副作用?上驳氖牵覈F(xiàn)在開發(fā)了安全高效的ε-poly-ICLC,為癌癥疫苗的開發(fā)提供了新的選擇。有意向的公司或?qū)嶒炇铱伤叫?。 2025-10-19 |
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Reference Nair SS, Chakravarty D, Balan S, et al. Abstract CT023: Prostate cancer in situ autovaccination with the intratumoral viral mimic poly-ICLC: making a cold tumor hot. Cancer Res. 2024;84(suppl 7):CT023. doi:10.1158/1538-7445.AM2024-CT023 TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial Nature Communications volume 15, Article number: 3882 (2024) Combined Vaccination with NY-ESO-1 Protein, Poly-ICLC, and Montanide Improves Humoral and Cellular Immune Responses in Patients with High-Risk Melanoma Anna Pavlick et al. Cancer Immunol Res. 2020 Jan;8(1):70-80. |
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References Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets Nina Bhardwaj et al. Nat Cancer. 2020 Dec. A Phase Ib Study of Indirect Immunization with Oregovomab and Toll-like-Receptor-3 Stimulation with Hiltonol® in Patients with Recurrent Platinum-Resistant Ovarian Cancer Robert W Holloway et al. Curr Oncol. 2025. 337 Intratumoral immune therapy for recurrent breast cancer with polyICLC, and tremelimumab combined with systemic durvalumab Journal for ImmunoTherapy of Cancer (Volume 9, Issue Suppl 2) |
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